Zhentao Zhang Selected Research

Synucleinopathies

12/2023	Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo.
10/2023	SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy.
1/2023	Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.
1/2021	Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.
8/2017	Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
1/2017	α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

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Zhentao Zhang Research Topics

Disease

57	Parkinson Disease (Parkinson's Disease) 07/2024 - 11/2009
23	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 02/2014
14	Neoplasms (Cancer) 04/2024 - 12/2004
13	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2024 - 04/2014
8	Cognitive Dysfunction 07/2023 - 01/2018
7	Dyskinesias (Dyskinesia) 01/2022 - 04/2009
6	Mitochondrial Diseases (Mitochondrial Disease) 02/2024 - 01/2022
6	Synucleinopathies 12/2023 - 01/2017
4	Neoplasm Metastasis (Metastasis) 04/2024 - 12/2020
4	Neuroinflammatory Diseases 01/2023 - 01/2020
4	Amyloid Plaque 01/2021 - 01/2018
4	Prostatic Neoplasms (Prostate Cancer) 12/2019 - 01/2010
3	Parkinsonian Disorders (Parkinsonism) 11/2023 - 09/2022
3	Carcinogenesis 10/2022 - 01/2010
3	Infections 05/2022 - 01/2013
3	Body Weight (Weight, Body) 10/2021 - 08/2002
3	COVID-19 08/2020 - 01/2020
3	Stroke (Strokes) 10/2016 - 01/2011
2	Tauopathies 11/2023 - 10/2023
2	Reperfusion Injury 08/2023 - 01/2021
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2023 - 01/2022
2	Heart Failure 10/2021 - 11/2019
2	Memory Disorders (Memory Loss) 01/2019 - 02/2014
1	Hepatocellular Carcinoma (Hepatoma) 04/2024
1	Hepatitis 12/2023
1	Cerebrotendinous Xanthomatosis 11/2023
1	Proteinuria 11/2023
1	Nervous System Diseases (Neurological Disorders) 11/2023
1	Lung Injury 08/2023
1	Acute Lung Injury 08/2023

Drug/Important Bio-Agent (IBA)

30	SynucleinsIBA 07/2024 - 01/2017
18	Proteins (Proteins, Gene)FDA Link 05/2024 - 08/2002
15	asparaginylendopeptidase (legumain)IBA 07/2023 - 11/2014
13	Amyloid (Amyloid Fibrils)IBA 05/2024 - 11/2015
9	RotenoneIBA 01/2020 - 11/2009
7	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 04/2009
6	Neuroprotective AgentsIBA 02/2024 - 01/2011
6	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021 - 01/2017
5	Dopamine (Intropin)FDA LinkGeneric 01/2020 - 01/2014
4	Peptides (Polypeptides)IBA 04/2024 - 11/2015
4	PrionsIBA 03/2024 - 10/2022
4	Peptide Hydrolases (Proteases)FDA Link 11/2023 - 01/2018
4	CytokinesIBA 01/2023 - 01/2018
4	6,7-dihydroxyflavoneIBA 01/2022 - 02/2014
3	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2023 - 12/2020
3	Biomarkers (Surrogate Marker)IBA 08/2023 - 01/2020
3	Cofilin 1IBA 01/2023 - 01/2020
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2022 - 10/2017
3	CholesterolIBA 05/2021 - 08/2002
3	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2020 - 03/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2014
3	ProdrugsIBA 01/2020 - 10/2016
2	Amino Acids FDA Link 04/2024 - 01/2020
2	Prion ProteinsIBA 03/2024 - 11/2023
2	CCAAT-Enhancer-Binding ProteinsIBA 07/2023 - 01/2018
2	Islet Amyloid PolypeptideIBA 07/2023 - 01/2022
2	RNA (Ribonucleic Acid)IBA 01/2023 - 10/2022
2	ManebIBA 01/2023 - 12/2022
2	PesticidesIBA 12/2022 - 01/2020
2	Pyrethrins (Pyrethroids)FDA Link 09/2022 - 12/2020
2	BoronIBA 03/2022 - 01/2019
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2022 - 12/2015
2	EnzymesIBA 01/2022 - 01/2022
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 01/2018
2	fenpropathrinIBA 12/2020 - 03/2016
2	Apolipoproteins E (ApoE)IBA 01/2020 - 01/2018
2	Amantadine (Aman)FDA LinkGeneric 01/2020 - 01/2014
2	Androgen Receptors (Androgen Receptor)IBA 12/2019 - 01/2015
2	N-propionylprocainamideIBA 11/2019 - 01/2019
2	Zalcitabine (Hivid)FDA Link 01/2019 - 10/2017
2	Oxidopamine (6 Hydroxydopamine)IBA 01/2017 - 12/2015
2	Vitamin D FDA LinkGeneric 10/2011 - 01/2010
2	hydroxide ionIBA 01/2010 - 12/2004
1	Amyloidogenic ProteinsIBA 05/2024
1	Peptide Transporter 1IBA 04/2024
1	DipeptidesIBA 04/2024
1	alpha-SynucleinIBA 12/2023
1	sodium-bile acid cotransporterIBA 12/2023
1	Cholestanol (Coprostanol)IBA 11/2023
1	27-hydroxycholesterolIBA 11/2023
1	SARS-CoV-2 spike proteinIBA 10/2023
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 08/2023
1	InterleukinsIBA 08/2023
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 08/2023
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2023
1	Endothelin-1 (Endothelin 1)IBA 08/2023
1	Follicle Stimulating Hormone (Follitropin)FDA Link 07/2023
1	Glycogen Synthase Kinase 3 betaIBA 01/2023
1	AutoantibodiesIBA 01/2023
1	Actin Depolymerizing Factors (Cofilins)IBA 01/2023
1	RadiopharmaceuticalsIBA 01/2023
1	Apolipoprotein E4IBA 01/2023

Therapy/Procedure

10	Therapeutics 12/2023 - 09/2013
3	Oral Administration 01/2020 - 02/2014
2	Drug Therapy (Chemotherapy) 08/2022 - 12/2020
2	Boron Neutron Capture Therapy 03/2022 - 01/2019
2	Ligation 10/2021 - 01/2020
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 05/2020 - 01/2015
2	Castration 12/2019 - 10/2011
1	Immunotherapy 01/2023